Tag Archives: Charan

Jacob’s Sheep: Genetics and Epigenetics in the Torah

geneticsThis week’s parasha is Vayetze, where we read of Jacob’s arrival in Charan and the details of his twenty-year sojourn there. During this time, Jacob married (twice), had a dozen children, and toiled for his cruel father-in-law Laban. Laban recognized that he had been blessed exceedingly on account of Jacob’s presence, and offered him a new wage for his labour. By this point, Jacob knew not to trust the sly Laban, and asked simply for ownership of all the speckled and spotted sheep. Since these imperfect-looking sheep were few in number, Laban readily agreed. It appears that both Laban and Jacob were well aware of the basic principles of genetics. Today, we know that sheep have 17 or so different colour alleles, and white colour is the dominant one.

For those who have forgotten high school biology: An allele is a variation of a gene. So, for example, all humans have a gene for eye colour, but have different alleles that code for the varying colours: some have alleles for blue eyes, while others have brown eyes, etc. Each person has two alleles for every gene – one from their mother, and one from their father. Certain alleles are “dominant”, while others are “recessive”. Dominant alleles are far more likely to be expressed. In humans, brown eye colour is dominant to blue eye colour, which is why some 55% of people have brown eyes, while only about 8% have blue eyes.

Basic "Punnet squares" showing the probabilities of eye colour for the children of fully brown-eyed and blue-eyed parents, and a brown-eyed parent who carries a blue allele.

Basic “Punnet squares” showing the probabilities of eye colour for the children of fully brown-eyed and blue-eyed parents, and a brown-eyed parent who carries a blue allele. (Courtesy: The University of North Carolina at Chapel Hill)

White is the dominant allele for sheep colour, so Laban assumed he was getting a terrific deal from Jacob, who was apparently ignorant of sheep genetics. In reality, Jacob knew sheep genetics quite well, and had something else up his sleeve. He only offered Laban this deal because he knew the greedy Laban would readily agree to it. So, how would Jacob outwit his father-in-law?

A Brief Introduction to Epigenetics

Jacob was evidently a far more knowledgeable geneticist than Laban, as he was aware of a concept that has only come to light in recent decades, called epigenetics. Epigenetics refers to various layers of heritability and genetic effects which are above, or outside of (hence the Greek prefix epi), the actual genetic code. In 2008, scientists defined an epigenetic trait as “stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence.” In simple terms: the chromosome that contains the genes is altered in some way without affecting the DNA sequence (the genetic code) itself. That alteration is heritable, too, and passed down from one generation to the next.

A number of epigenetic mechanisms have been discovered. The most common are methylations and acetylations, where small molecules are attached or removed from the DNA strand, causing it to coil either more tightly or less tightly. When the DNA coils more tightly, the gene is rendered inaccessible, and cannot be expressed. If uncoiled, the gene is exposed, and can be translated into the protein it codes for, thus expressing the trait.

Coiling of DNA and gene expression. (Courtesy: National Institutes of Health)

Coiling of DNA and gene expression. (Courtesy: National Institutes of Health)

While epigenetics is quite complicated, its implications are tremendous. What it means in practical terms is that even though a person has a certain gene, that gene does not necessarily have to be expressed, as it can be silenced through epigenetic mechanisms. For example, a person who has a gene that predisposes them to cancer, God forbid, could potentially have that gene suppressed, thus eliminating their increased cancer risk. (Though they don’t work in this precise fashion, epigenetic cancer drugs are now available.) This also applies to people who might be genetically predisposed to obesity, diabetes, Alzheimer’s, or theoretically, any trait at all. A person who has both brown and blue alleles does not necessarily have to have brown eyes (which is what we would expect based on principles of classical, or Mendelian, genetics). The brown eye allele can be silenced, allowing the blue allele to be expressed fully.

The same is true for Jacob’s sheep. While the alleles for speckled and spotted sheep are recessive, the dominant white allele can be suppressed, resulting in more speckled and spotted sheep. In the Torah, we read how Jacob took tree branches and stripped away some of their bark to expose the inner white layers so that their pattern resembled that of the speckled and spotted sheep. He then placed these branches in front of the white sheep that were mating, and this resulted in the white sheep producing more speckled and spotted offspring. In this way, Jacob was quickly able to multiply the number of irregular-looking sheep in the flocks, increasing his own wealth, and leaving Laban in utter surprise.

What does science have to say about this? Is it really possible for the white sheep to produce speckled and spotted offspring just by looking at speckled and spotted tree branches? Which factors actually affect epigenetics?

The Epigenetics Revolution

In northern Sweden lies a small, isolated town called Överkalix. This town kept detailed historical records, including births, illnesses, and deaths, as well as harvests and food prices. Researchers started poring over this data and noted a number of emerging patterns. Surprisingly, those who grew up in times of relative abundance tended to live shorter and sicker lives, while those who grew up in times of relative famine were healthier and lived longer! Even more shocking was that these traits passed on to their children and grandchildren. The grandsons of those who grew up in times of abundance lived roughly six years less than grandsons of those who grew up in times of famine!

The Överkalix study opened the door to much more research on the subject, and today we know that not only does food impact our epigenetics, but so does smoking, alcohol, exercise, and just about every lifestyle choice we make. Moreover, recent studies find that not only do our actions impact our epigenetics, but even our thoughts do! In 2013, scientists discovered that meditation affects epigenetic mechanisms and results in, among other things, less inflammation in the body, better stress responses, and faster mental processes.

TIME Magazine Feature on Epigenetics

TIME Magazine Feature on Epigenetics

Epigenetics has brought about a revolution in biology, and a new realization that we are not slaves to our genome. We are very much in control of how our genes operate, and seemingly every choice we make affects our health and wellbeing, as well as the health and wellbeing of our children and grandchildren, since these epigenetic patterns are heritable. This is one of the most enlightening and liberating scientific findings, putting each person in the driver’s seat of their biological fate. It should also motivate us to make healthy lifestyle choices because, even if we might not care so much about our own health, the health of our offspring is directly impacted by our choices.

The Return of Jacob’s Sheep

If meditation plays a role in how our genes are expressed, there is no reason why other mental processes cannot do the same. By visually exposing his sheep to speckled and spotted images, Jacob may very well have triggered an epigenetic change resulting in suppression of white alleles. Neurologists have long known that there is essentially no difference in brain patterns when a person is literally seeing something versus when they are simply visualizing the same thing. If mental visualizations like meditation can affect the epigenome, then why not actual visual displays? Armed with this knowledge, Jacob outwitted his father-in-law and became an exceedingly wealthy man.

Of course, one cannot deny God’s role in the process, as Jacob himself explained to his wives (Genesis 31:7-9):

…your father mocked me and changed my wages ten times, but God did not permit him to harm me. If he would say, “Speckled ones shall be your wages,” all the animals would bear speckled ones, and if he would say, “Ringed ones shall be your wages,” all the animals would bear ringed ones. Thus, God separated your father’s livestock and gave it to me…

Changing one’s epigenetics is not so simple! As with everything else, a little help from Above is always needed. Jacob put in his effort by exposing the animals to stimulating sights, and God took care of the rest.

Jacob's sheep are unique not only in their colour, but also in that the rams have extra horns.

Jacob’s sheep are unique not only in their colour, but also in that the rams have extra horns.

Interestingly, this week saw the arrival of 119 “Jacob’s sheep” to Israel. This ancient breed of sheep originated in the Middle East approximately 5000 years ago. They were extirpated from the land of Israel long ago, but thankfully some survived and were brought across North Africa to Europe and finally America. The rare speckled and spotted sheep are in the Holy Land once more, perhaps a sign of the forthcoming return of all of Jacob’s children to their ancestral home.


 

The above is an excerpt from Garments of Light: 70 Illuminating Essays on the Weekly Torah Portion and Holidays. Click here to get the book! 

What It Really Means to Be “Israel”

This week’s parasha, Vayishlach, begins with Jacob’s return to the Holy Land following a twenty-year stay in Charan. The most famous passage of this parasha is Jacob’s battle with a certain angel. After its defeat, the angel gives Jacob a blessing and renames him Israel. What is the meaning of “Israel”? What was the purpose of this battle to begin with? And what does it all have to do with Jacob’s difficult twenty years in servitude to his deceiving father-in-law Laban?

Jacob vs. Esau

The Torah describes in quite some detail the conception, birth, and early lives of the twins Jacob and Esau. We see that Jacob was an “innocent man, sitting in tents” while Esau was a “hunter, a man of the field.” As twins, and the only children of Isaac and Rebecca, they were meant to work together in carrying on the divine mission started by their grandfather Abraham. The mission was to rectify the world, and fill it with true Godliness and righteousness. Such work mainly consists of educating others, doing good, and spreading the light. However, when that doesn’t work, it is also necessary to fight evil head-on. This was exemplified well by Abraham, who was both a wonderful preacher and, occasionally, a fearless warrior (as in the “War of the Kings” in Genesis 14).

Jacob and Esau were meant to take this to the next level. Thus, Jacob was blessed with extra intellect, wit, and spirituality, while Esau was blessed with extra strength, physical abilities, and ambition. In an ideal world, Jacob would have acted as the peaceful teacher, while Esau would defeat any remaining evil in battle. As partners, they would have been unstoppable in bringing light, morality, and a new God-consciousness to the world.

Unfortunately, the two couldn’t channel their blessings in the right direction. Esau’s physicality got the better of him, and he descended into a never-ending spiral of materialism. At the same time, Jacob used his cunning to take Esau’s birthright instead of using his intellect to put his brother back on the right path. Nonetheless, Jacob remained dedicated to fulfilling his divine mission, while Esau “despised his birthright” (Genesis 25:34).

By taking Esau’s birthright and blessing, what Jacob had done was to take Esau’s mission upon himself. He, too, would have to become a fighter. However, Jacob was born soft and meek—not fit for battle—while Esau was the one born muscular and hairy, as if already a grown man (hence his name Esav, literally “complete”). Could Jacob really become that holy warrior that Esau was meant to be? Jacob had to be put to the test.

Becoming Israel

Right after receiving Esau’s blessings, Jacob was told that his brother was out to get him. The soft Jacob immediately fled the Holy Land, as far away from his brother as he could. This was true to his character as a docile man, “sitting in tents”. But this was clearly not what a holy warrior would do.

Jacob ended up in the home of his uncle and future father-in-law, Laban. He instantly fell in love with Laban’s younger daughter Rachel, and agreed to work for Laban for seven years to be able to marry her. After seven years, Jacob was tricked into marrying the elder Leah instead of his beloved Rachel. It is hard to miss the irony of it all: Jacob, the one who tricked his father into getting his older brother’s blessing, is now tricked by his father-in-law into marrying his beloved’s older sister!

Laban forces Jacob to work for another seven years. This is, of course, completely unjust. A man such as Esau would have surely taken on Laban in combat, but the spineless Jacob simply agrees, and slaves away for seven more years. Following this, Laban finds more ways to trick Jacob out of an honest wage. Thankfully, Jacob is starting to learn, and begins to counter Laban’s wits with his own, soon building even greater wealth than his father-in-law.

At this point, Jacob hears that Laban is not very pleased with Jacob, and Jacob fears for himself and his family once again. As he did twenty years earlier, he decides to flee. While Laban was away shearing his sheep, Jacob takes the opportunity to run, taking the whole family with him. It appears that Jacob fails the test yet again, and is unable to confront his evil enemies.

Ten days later, Laban and his men find Jacob, and everything begins to change. Laban waltzes in to Jacob’s camp and begins threatening his son-in-law as he’d always done in the past. But this time Jacob has had enough, and realizes he can’t run away anymore. “And Jacob was angered, and battled with Laban” (Genesis 31:36). Jacob succeeds, and Laban seeks a peace treaty (v. 44). The two make a pact and part ways, never to see each other again. Jacob is becoming a fighter.

Jacob vs. Israel

This sets up parashat Vayishlach, where Jacob has to face off with Esau twenty years after running away from him. The night before, Jacob goes off on his own and is confronted by a mysterious figure (see ‘With Whom Did Jacob Wrestle? in Volume One of Garments of Light). The two battle it out all night long, and Jacob finally prevails. He is certainly no longer that weak, passive man he was two decades earlier. He has earned his badge of being a holy warrior. And with this, he is given a new name: Israel, one who “battles with God”; not against God, but alongside God, to defeat evil and make the world a better place. Jacob finally proves that he can indeed be Esau, and is worthy of having taking Esau’s birthright and blessing.

The Sages tell us that this is the real reason why Jacob had to marry both Rachel and Leah. Originally, since Rebecca had two sons and Laban had two daughters, the plan was for the younger Jacob to marry the younger Rachel, while the older Esau would marry the older Leah (Bava Batra 123a). Truly, these two couples were soulmates. However, Esau lost his spiritual essence to Jacob, and with it, his spiritual counterpart, Leah. The problem is that the Torah forbids a man from marrying two sisters! The Arizal (Sha’ar HaPesukim on Vayetze) tells us that, in fact, Rachel and Leah did not marry one man, for Jacob and Israel were really two souls in one body, and while Jacob married Rachel, it was Israel that married Leah. After all, Israel was the new Esau, the part of Jacob that wasn’t just “sitting in tents” but was capable of being a “man of the field”, too.

We later see that Israel was Jacob’s true self, his more-elevated inner being, and what he was really meant to be all along. God confirms this with a prophetic blessing (Genesis 35:10): “‘You shall no longer be called Jacob, but Israel shall be your name.’ And He named him Israel.”

This brings a tremendous lesson for all of us: we are not meant to be the weak Jacob, passively sitting in tents and being pushed around. Rather, we are meant to be Israel, who can balance study and prayer with strength and might; who can balance the physical with the spiritual, science with religion, and who knows both when to seek peace and when to pursue war. It is most fitting that the founders of the modern Jewish State decided to call it “Israel”. (In fact, they had originally planned to call it “Judah”, then “Zion”, and even “Tzabar”, before voting 7 to 3 in favour of “Israel”). If Israel is to fulfill its divine task, it should live up to its name: battling alongside God, as holy, righteous warriors, to repair the world—physically and spiritually—restoring it to its original, perfected state.


The above is an excerpt from Garments of Light, Volume Two. Get the book here